Chen Jinghong

Current Research Domain：Etiology and pathogenesis of EndemicDiseases

Educational Background:

07/1982 -07/1987Xi’an medical universityClinical MedicineB. A

09/1993 -07/1996Xi’an medical universityPathologyM. D

09/2001-05/2005Xi’an Jiaotong Universtity School of MedicinePathogenic BiologyPh.D

Professional Positions and Employment

07/1987- 09/1993Yan’an UniversityTeachingAssistant

09/1996-10/ 2005Xi’an Medical UniversityInstructor in Medicine

10/2005-12/ 2014Xi’an Jiaotong Universtity School of MedicineAssociate Professor of Medicine

12/2014-Xi’an Jiaotong Universtity School of MedicineProfessor of Medicine

Bibliography: (The First author or corresponding author*)：

[1] Liu H, Fang Q, Wang M, Wang W, Zhang M, Zhang D, He Y, Zhang Y, Wang H, Otero M, Ma T,Chen J*.FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.Biochem Biophys Res Commun. 2018; 500(2):184-190.

[2]He Y, Zhang Y, Dan Zhanga, Meng Zhanga, Mengying Wanga, Zhuocheng Jianga,Miguel Oteroc, Chen J*.3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.Biomedicine & Pharmacotherapy. 2018;106:1696-1704

[3]Yang HJ, Zhang Y, Wang ZL, Xue SH, Li SY, Zhou XR, Zhang M, Fang Q, Wang WJ, Chen C, Deng XH, Chen JH.Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency.Biomed Environ Sci. 2017;30(5):351-362.

[4] Zhou X, Yang H, Guan F, Xue S, Song D,Chen J*, Wang Z.T-2 Toxin Alters the Levels of Collagen II and Its Regulatory Enzymes MMPs/TIMP-1 in a Low-Selenium Rat Model of Kashin-Beck Disease.Biol Trace Elem Res, 2016; 169(2), 237-46.

[5]Chen J, Luo M, Wang W, Zhang Z, He Y, Duance VC, Hughes CE, Caterson B, Cao J.Altered proteolytic activity and expression of MMPs and aggrecanases and their inhibitors in Kashin-Beck disease.J Orthop Res. 2015;33(1):47-55.

[6]Ma T,Wang Z,Yang Z,Chen J*. Cluster of differentiation 147 is a key molecule during hepatocellular carcinoma cell-hepatic stellate cell cross-talk in the rat liver.Mol Med Rep.2015;12 (1):111-8.

[8]Luo M,Chen J,Li S, Sun H, Zhang Z, Fu Q, Li J, Wang J, Hughes CE, Caterson B, Cao J.Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease.Osteoarthritis Cartilage. 2014;22(7):986-95.

[9] W.Wang, S. Wei, M. Luo, B. Yu, J. Cao, Z. Yang, Z. Wang, M.B. Goldring,Chen J*. Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease. Osteoarthritis and Cartilage. 2013 ; 21 :1781-1789

[10]Chen JH, Xue S, Li S, Wang ZL, Yang H, Wang W, Song D, Zhou X, Chen C. Oxidant Damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions. J Orthop Res. 2012; 30(8):1229-1237.

[11] Guan F, Li S, Wang ZL, Yang H, Xue S, Wang W, Song D, Zhou X, Zhou W,Chen J*, Caterson B, Hughes C. Histopathology of Chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and Selenium deficiency conditions. Rheumatol Int. 2013; 33(1):157-166.

[12]Chen J, Chu Y, Cao J, Wang W, Liu J, Wang J.Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), α2-macroglobulin (α2M) and TIMPs.Toxicol In Vitro. 2011;25(2):492-499.

[13] Zhou X, Wang ZL, Wang W, Song D, Li S, Yang H, Xue S, Chen Chen,Chen JH*. Increased levels of IL-6, IL-1β and TNF-α in Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. Rheumatol Int. 2014; 34(7):995-1004

[14]Chen J, Jun-ling Cao, Chu Y, Wang Z, Yang Z, Wang H.T-2 toxin induced apoptosis involving Fas, P53, Bcl-xL, Bcl-2, Bax and Caspase-3 signaling pathway in chondrocytes. J Zhejiang Univ Sci B.2008; 9(5)455-465 .

[15]Chen J, Chu Y, Cao J, Yang Z, Guo X, Wang Z. T-2 toxin induces apoptosis, and selenium partly blocks, T-2 induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. Food and Chemical Texicology. 2006; 44(4)567-573.

Contact information:

Email：jixiang46@13.com

Cell phone：13087580882

Office address：Institute of Endemic Diseases, School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an 710061, Shaanxi, China.